反应详情

The product from Example 14.1 (0.048 g, 0.274 mmol) was reductively aminated with 5-(benzyloxymethyl)-4-methoxy-5H-pyrrolo[3,2-d]pyrimidine-7-carbaldehyde (0.081 g, 0.274 mmol) and sodium triacetoxyborohydride (0.075 g, 0.356 mmol) in the same way as described for the R-enantiomer in Example 13.2. to give (S)-2-(((5-(benzyloxymethyl)-4-methoxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)amino)ethanol (100 mg, 80%) as a colourless gum which slowly turned pale yellow. The 1H and 13C NMR were as described for the R-enantiomer in Example 13.2. +ESMS Found 457.2469 C24H33N4O5 (M+H)+ requires 457.2451.