HRID533504

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID5142091

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine

C5H11NO2

结构：CC1(C)OB(c2ccc(CCC(C)(C(=O)O)S(C)(=O)=O)cc2)OC1(C)C

HCID66578008

未命名化合物

结构：CC(CCc1ccc(Br)cc1)(C(=O)NOC1CCCCO1)S(C)(=O)=O

HCID76445393

未命名化合物

PRODUCTS

生成物

结构：CC1(C)OB(c2ccc(CCC(C)(C(=O)NOC3CCCCO3)S(C)(=O)=O)cc2)OC1(C)C

HCID76445394

未命名化合物

收率 60.4%

PROCEDURE

实验过程

The title compound (3.69 g, 60.4%) was prepared from (+/−)-2-methyl-2-(methylsulfonyl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]butanoic acid (4.86 g, 12.7 mmol) and O-tetrahydro-2H-pyran-2-yl-hydroxylamine (2.1 g, 18.0 mmol) by a procedure analogous to that described for (+/−)-4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide (III/Step 4—Preparation Number 2). LCMS m/z 480.3 (M−1).