反应详情

To a stirred solution of methyl 3-(4-(3-chloro-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate (Reference Example 36, 0.386 g, 1.16 mmol) in methanol (10.0 mL) was added sodium hydroxide (1.50 mL, 1.0 M in water, 1.50 mmol) at room temperature. After 16 h, the reaction was quenched with 1.0 M hydrochloric acid (1.70 mL), diluted with ethyl acetate, washed with water, and saturated sodium chloride, dried (Na2SO4), filtered and concentrated under reduced pressure. The residue was triturated with methylene chloride and hexanes to provide 3-(4-(3-chloro-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid (0.316 g, 85%) as a white powder.

1. customthe reaction was quenched with 1.0 M hydrochloric acid (1.70 mL)
2. additiondiluted with ethyl acetate
3. washwashed with water, and saturated sodium chloride
4. dry with materialdried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure
7. customThe residue was triturated with methylene chloride and hexanes