反应详情

The product of Example 1B and 2-(3-phenoxyphenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.30 (dd, J=7.9, 1.3 Hz, 1H), 8.03 (d, J=8.0 Hz, 1H), 7.97-8.01 (m, 1H), 7.89-7.93 (m, 1H), 7.36-7.43 (m, 3H), 7.14-7.18 (m, 2H), 7.00-7.08 (m, 3H), 6.91 (dd, J=8.2, 2.5 Hz, 1H), 3.80-3.85 (m, 4H), 3.67 (s, 2H) 3.06-3.12 (m, 4H); MS (ESI+) M/Z 457 (M+H)+.