反应详情

The title compound was synthesized from N-cyclopropyl-6-ethynylpyridazin-3-amine and 2-(3-iodo-4-methylphenyl)-6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazole (as prepared in Example 1) in a manner similar to that described for in Example 1. The intermediate compound N-cyclopropyl-6-ethynylpyridazin-3-amine was made as for Example 1 (Step 1 to 3) with the spectra below: 1H NMR (300 MHz, CDCl3) δ: 7.38-7.41 (1H, d, J=9.0 Hz), 6.96-6.99 (1H, d, J=9.0 Hz), 5.99 (1H, s), 3.25-3.27 (1H, m), 2.57 (1H, s), 0.87-0.89 (2H, s), 0.61-0.63 (2H, s).