HRID535842
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
PROCEDURE
实验过程
The title compound was synthesized from N-isopropyl-6-ethynylpyridazin-3-amine and 4-chloro-3-iodo-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide in a manner similar to that described for in Example 1. The product was obtained as a pale yellow solid. Mp: 133-134° C.; 1H NMR (300 MHz, CDCl3) δ: 9.62 (1H, s), 8.11 (1H, s), 8.05 (1H, s), 8.01-8.03 (1H, d, J=9.0 Hz), 7.86-7.88 (1H, d, J=6.0 Hz), 7.60-7.63 (1H, d, J=6.0 Hz), 7.44-7.47 (1H, d, J=9.0 Hz), 7.33-7.36 (1H, d, J=9.0 Hz), 6.63-6.66 (1H, d, J=9.0 Hz), 3.99-4.07 (1H, m), 3.67 (2H, s), 2.84 (8H, brs), 2.56 (3H, s), 1.25-1.30 (6H, m). HRMS (ESI-TOF+): m/z [M+H]+ calcd for C29H30ClF3N6O: 571.2194. found: 571.2209.
WORKUP
后处理
- customThe product was obtained as a pale yellow solid