反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
PROCEDURE
实验过程
The title compound was synthesized from N-cyclobutyl-6-ethynylpyridazin-3-amine and 4-chloro-3-iodo-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide in a manner similar to that described for in Example 1. The product was obtained as a pale yellow solid. Mp: 225-227° C.; 1H NMR (300 MHz, DMSO-d6) δ: 10.82 (1H, s), 8.35 (1H, d, J=2.1 Hz), 8.27 (1H, s), 8.13 (1H, s), 7.99-8.03 (1H, dd, J=2.1 and 8.1 Hz), 7.81-7.84 (1H, d, J=8.7 Hz), 7.76 (1H, s), 7.66-7.68 (2H, m), 7.46-7.49 (1H, d, J=9.0 Hz), 6.76-6.80 (1H, d, J=9.3 Hz), 4.40 (1H, m), 2.32-2.34 (2H, m), 2.17 (3H, brs), 1.87-1.97 (2H, m), 1.71-1.76 (2H, m). HRMS (ESI-TOF+): m/z [M+2H]+2 calcd for C28H24ClF3N6O: 276.0821. found: 276.0819.
WORKUP
后处理
- customThe product was obtained as a pale yellow solid