反应详情

To (S)-1-(2-((R)-3-fluoropyrrolidin-1-yl)ethyl)-4-isopropyl-3-(3-(4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)imidazolidin-2-one (0.025 g, 0.0394 mmol) was added trifluoroacetic acid (5 mL) and the reaction stirred for 2 hours at ambient temperature. The reaction was concentrated in vacuo and the material purified by reverse preparative HPLC to give (S)-3-(3-(4-(1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-((R)-3-fluoropyrrolidin-1-yl)ethyl)-4-isopropylimidazolidin-2-one (0.0143 g, 0.0284 mmol, 72.0% yield) as the bis TFA salt. LCMS (APCI+) m/z 504 [M+H]+.

1. concentrationThe reaction was concentrated in vacuo
2. customthe material purified by reverse preparative HPLC