反应详情

In the atmosphere of argon, 19.7 g of 2′-fluoro-2,3-dimethoxybiphenyl and 500 mL of anhydrous THF were placed in a flask. 56 mL of a hexane solution of 1.6M n-butyllithium was added, and the reaction solution was stirred at room temperature for 4 hours. After cooling to −78° C., 30 mL of a THF solution of 27.8 g of trimethyl borate was added dropwise. While heating to room temperature, the reaction solution was stirred for 8 hours. 200 mL of 10% HCl was added to the reaction solution, and the resulting mixture was stirred for 2 hours. The reaction solution was extracted with ether. An aqueous phase was removed, and then an organic phase was washed with saturated saline. After drying the organic phase with magnesium sulfate, the organic phase was concentrated, and residues were washed with hexane, whereby 15.2 g (yield: 65%) of 2′-fluoro-2,3-dimethoxybiphenyl-4-boronic acid was obtained.

1. temperatureAfter cooling to −78° C.
2. temperatureWhile heating to room temperature
3. stirringthe reaction solution was stirred for 8 hours
4. stirringthe resulting mixture was stirred for 2 hours
5. extractionThe reaction solution was extracted with ether
6. customAn aqueous phase was removed
7. washan organic phase was washed with saturated saline
8. dry with materialAfter drying the organic phase with magnesium sulfate
9. concentrationthe organic phase was concentrated
10. washresidues were washed with hexane