反应详情

5-Chloro-3-[3-(trifluoromethyl)phenyl]pyridazine (2 g, 0.0077 mole, Compound No. 5), 2.5N NaOH (50 mL) and DMSO (100 mL) were refluxed under N2 for 2 h. The mixture was then allowed to cool and made acidic with 12N HCl and extracted 3×100 mL with ethyl acetate. The organic layer was dried (MgSO4), filtered and evaporated in vacuo to give a crude solid which was recrystallized from methanol to give 6-[3-(trifluoromethyl)phenyl]-4-pyridazinol (1 g, 54% yield, Compound No. 25) as a light brown solid.

1. temperatureto cool
2. extractionextracted 3×100 mL with ethyl acetate
3. dry with materialThe organic layer was dried (MgSO4)
4. filtrationfiltered
5. customevaporated in vacuo
6. customto give a crude solid which
7. customwas recrystallized from methanol