反应详情

To a mixture of 4,7-dihydro-6-ethoxycarbonyl-2-(4-fluorophenyl)-3-(pyridin-4-yl)-7-oxopyrazolo[1,5-a]pyrimidine (100 mg) in tetrahydrofuran (4 ml) was added lithium borohydride (2 mole in tetrahydrofuran, 0.26 ml) at room temperature and the mixture was refluxed for 1 hour. After cooling, the reaction mixture was quenched with an aqueous saturated ammonium chloride solution and extracted with ethyl acetate. The extracts were washed with brine, dried and concentrated in vacuo. The residue was crystallized from ethanol to give 6-ethoxycarbonyl-2-(4-fluorophenyl)-7-oxo-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (40 mg).

1. temperaturethe mixture was refluxed for 1 hour
2. temperatureAfter cooling
3. customthe reaction mixture was quenched with an aqueous saturated ammonium chloride solution
4. extractionextracted with ethyl acetate
5. washThe extracts were washed with brine
6. customdried
7. concentrationconcentrated in vacuo
8. customThe residue was crystallized from ethanol