HRID549964

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID596118

[5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid

C7H7F3N2O2

$结构：CC(C)(C)OC(=O)N1CCC(c2nc(/C=C\c3cccc4ccccc34)cs2)CC1$

HCID67156180

未命名化合物

PRODUCTS

生成物

$结构：Cc1cc(C(F)(F)F)nn1CC(=O)N1CCC(c2nc(/C=C\c3cccc4ccccc34)cs2)CC1$

HCID67156519

未命名化合物

PROCEDURE

实验过程

tert-Butyl 4-{4-[(Z)-2-(naphthalen-1-yl)ethenyl]-1,3-thiazol-2-yl}piperidine-1-carboxylate (IV-3, 171 mg) is deprotected analogously to Example II-2 and then reacted analogously to Example I-81 with [5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid (100 mg). After chromatographic purification, this gives 2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-(4-{4-[(E)-2-(naphthalen-1-yl)ethenyl]-1,3-thiazol-2-yl}piperidin-1-yl)ethanone (200 mg).

WORKUP

后处理

customAfter chromatographic purification