Allyl bromide → HCID 22923365, compound

HRID 55024Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]=[C:6]2[N:15]1[CH2:20][CH2:19][CH:18]([N:21]2[C:30](=[O:31])[C:29]3[C:24](=[CH:25][CH:26]=[C:27]([CH3:32])[CH:28]=3)[NH:23][C:22]2=[O:33])[CH2:17][CH2:16]1.[CH2:34](Br)[CH:35]=[CH2:36]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]=[C:6]2[N:15]1[CH2:16][CH2:17][CH:18]([N:21]2[C:30](=[O:31])[C:29]3[C:24](=[CH:25][CH:26]=[C:27]([CH3:32])[CH:28]=3)[N:23]([CH2:36][CH:35]=[CH2:34])[C:22]2=[O:33])[CH2:19][CH2:20]1

Participants

Reactant 2

HCID 7841Allyl bromide

HCID 22923466HCID 22923466, compound

Product 1

HCID 22923365HCID 22923365, compoundYield 58%

Procedure

The procedure similar to that described in Example 1 was repeated, except that 300 mg (0.67 mmol) of Compound 22 was used in place of Compound 24 and allyl bromide was used in place of methyl iodide. As a result, 187.8 mg (yield: 58%) of Compound 53 was obtained as white crystals.

Sources & evidence

ORD record: ord-7431a8a9624d4b108586c69a8b466a64
Source dataset: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05624926

Reaction notes

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