反应详情

The title compound was prepared from 1-(6-chloro-pyridin-3-ylmethyl)-3-hydroxy-1H-thieno[3,2-d]pyrimidine-2,4-dione and 2-trifluoromethyl phenylboronic acid via general procedure C. The crude product was purified by mass-triggered preparative HPLC. 1H NMR (DMSO-d6) δ 10.78 (bs, 1H), 8.68 (d, 1H, J=2.1 Hz), 8.18 (d, 1H, J=5.4 Hz), 7.85 (d, 1H, J=8.1 Hz), 7.80 (dd, 1H, J=2.1, 8.1 Hz), 7.75 (t, 1H, J=7.5 Hz), 7.66 (t, 1H, J=7.8 Hz), 7.56-7.46 (m, 3H), 5.39 (s, 2H); Electrospray MS: 420 (M+H); retention time; 2.44 min.

1. customThe crude product was purified by mass-triggered preparative HPLC