反应详情

N-[(5-amino-8-hydroxyquinolin-7-yl)(phenyl)methyl]-2-phenoxyacetamide (200 mg, 0.5 mmol), dibromobutane (0.1 ml), TEA (0.2 ml) in isopropanol were heated at reflux for 16 h. The reaction mixture was concentrated in vacuo, the residue dissolved in methylene chloride, washed with brine. The organic layer was dried over sodium sulfate and filtered. To the filtrate was added 1M HCl/ether, the solids filtered, washed with ether to give N-[(8-hydroxy-5-pyrrolidin-1-ylquinolin-7-yl)(phenyl)methyl]-2-phenoxyacetamide as a purple solid.

1. temperatureat reflux for 16 h
2. concentrationThe reaction mixture was concentrated in vacuo
3. dissolutionthe residue dissolved in methylene chloride
4. washwashed with brine
5. dry with materialThe organic layer was dried over sodium sulfate
6. filtrationfiltered
7. additionTo the filtrate was added 1M HCl/ether
8. filtrationthe solids filtered
9. washwashed with ether