反应详情

The title compound was prepared following procedure described in Example 32, step c) from 2,2-dimethyl-6-[(4-{[4-(trifluoromethyl)phenyl]ethynyl}benzyl)amino]-4H-1,3-benzodioxin-4-one (427 mg; 0.95 mmol) and hexanal (Aldrich, 170 μl; 1.42 mmol) to give 560 mg of crude. Purification by flash chromatography on silica gel (EtOAc/c-Hexe 5:90 then 10:90) gave 395 mg (78%) of the title compound as a brown powder. HPLC, Rt: 6.21 min (purity: 68.5%). 1H NMR (CDCl3) δ: 7.59 (brs, 4H), 7.47 (m, 2H), 7.30.(m 3H), 6.76-6.83 (m, 2H), 4.50 (s, 2H), 3.38 (m, 2H), 1.68 (s, 6H), 1.61 (m, 2H), 1.28 (m, 6H), 0.86 (m, 3H).

1. customThe title compound was prepared following procedure
2. customto give 560 mg of crude
3. customPurification by flash chromatography on silica gel (EtOAc/c-Hexe 5:90