反应详情

Following the procedure as described in Example 2, making variations only as required to use (4-fluorophenyl)piperidin-4-ylmethanone to replace 3,3-difluoro-1-piperidin-4-yl-1,3-dihydroindol-2-one to react with 6-chloropyridazine-3-carboxylic acid (3-methylbutyl)amide in DMF, the title compound was obtained as a white powder in 36% yield. 1H NMR (300 MHz, CDCl3) δ 7.99-8.03 (m, 3H), 7.85-7.87 (m, 1H), 7.15-7.19 (m, 2H), 7.02 (d, J=9.6 Hz, 1H), 4.50-4.54 (m, 2H), 3.47-3.60 (m, 3H), 3.26-3.31 (m, 2H), 2.00-2.04 (m, 2H), 1.85-1.93 (m, 2H), 1.73-1.72 (m, 1H), 1.48-1.53 (m, 2H), 0.94 (d, J=6.6 Hz, 6H).