反应详情

Following the procedure as described in Example 4, making variations only as required to use 6-(3-aminopyrrolidin-1-yl)pyridazine-3-carboxylic acid (3-methylbutyl)-amide to replace 6-(6-amino-3-azabicyclo[3.1.0]hex-3-yl)pyridazine-3-carboxylic acid (2-cyclopropylethyl)amide to react with 2-trifluoromethylbenzoyl chloride, the title compound was obtained as a white powder in 99% yield. 1H NMR (300 MHz, CDCl3) δ 7.99 (d, J=9.3 Hz, 1H), 7.85 (t, J=5.6 Hz, 1H), 7.69 (d, J=7.7 Hz, 1H), 7.52-7.61 (m, 3H), 6.72 (d, J=9.4 Hz, 1H), 6.07 (d, J=7.0 Hz, 1H), 4.86-4.89 (m, 1H), 3.94-3.97 (m, 1H), 3.64-3.73 (m, 3H), 3.47 (dd, J=6.7 and 13.6 Hz, 2H), 2.42-2.49 (m, 1H), 2.20-2.26 (m, 1H), 1.64-1.75 (m, 1H), 1.47-1.51 (m, 2H), 0.93 (d, J=6.7 Hz, 6H). MS (ES+) m/z 450.4 (M+1).