HRID552244

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8082

Piperidine

C5H11N

HCID517165

Ammonium acetate

C2H7NO2

结构：CC1(C)CN(CC(=O)O)[C@H](C(=O)Nc2cc(Cl)cc3c2[nH]c2cnccc23)CO1

HCID11384512

(5S)-5-[[(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)amino]carbonyl]-2,2-dimethyl-4-morpholineacetic acid

C20H21ClN4O4

PRODUCTS

生成物

结构：CC1(C)CN(CC(=O)N2CCCCC2)[C@H](C(=O)Nc2cc(Cl)cc3c2[nH]c2cnccc23)CO1

HCID11605463

未命名化合物

收率 90%

PROCEDURE

实验过程

The desired compound was prepared according to Method F from [(S)-5-(6-Chloro-9H-beta-carbolin-8-ylcarbamoyl)-2,2-dimethyl-morpholin-4-yl]-acetic acid and piperidine in 90% yield. 1H-NMR (300 MHz, DMSO-d6): δ 1.17 (s,3H), 1.29 (s,3H), 1.35-1.60 (m,6H), 2.25 (d,1H), 2.71 (d,1H), 3.15 (d,1H), 3.26 (dd,1H), 3.37 (dd,1H), 3.45-3.65 (m, 2H), 3.65 (d, 1H), 3.70 (m, 1H), 3.89 (m, 2H) 7.95 (d,1H), 8.15 (d,1H), 8.20 (d,1H), 8.37 (d,1H), 9.01 (s,1H), 10.43 (s,1H), 11.32 (s,1H). Retention Time (LC, method: ammonium acetate standard): 1.86 min. MS (M+H+): 484.3.

WORKUP

后处理

custom1.86 min