HRID552247

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID77317

4-Pyridinemethanamine

C6H8N2

结构：CC1(C)CN(CC(=O)O)[C@H](C(=O)Nc2cc(Cl)cc3c2[nH]c2cnccc23)CO1

HCID11384512

(5S)-5-[[(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)amino]carbonyl]-2,2-dimethyl-4-morpholineacetic acid

C20H21ClN4O4

PRODUCTS

生成物

结构：CC1(C)CN(CC(=O)NCc2ccncc2)[C@H](C(=O)Nc2cc(Cl)cc3c2[nH]c2cnccc23)CO1

HCID11720347

未命名化合物

收率 53%

PROCEDURE

实验过程

The desired compound was prepared according to Method F from [(S)-5-(6-Chloro-9H-beta-carbolin-8-ylcarbamoyl)-2,2-dimethyl-morpholin-4-yl]-acetic acid and 4-(aminomethyl)pyridine. The product was isolated as hydrochloride salt in 53% yield. 1HNMR (300 MHz, D2O): δ 1.34 (s, 3H), 1.49 (s, 3H), 2.64 (d, 1H), 3.03 (d, 1H), 3.48 (d, 1H), 3.72 (t, 1H), 3.74 (d, 1H), 4.15-4.25 (m, 2H), 7.66 (d, 1H), 7.88 (s, 1H), 7.91 (s, 1H), 8.21(d, 1H), 8.44 (d,1H), 8.53 (d, 1H), 8.56 (s, 1H), 8.58 (s, 1H), 9.08 (s, 1H). Retention Time (LC, method: ammonium acetate standard): 1.47 min. MS (M+H+): 507.3.