反应详情

Method H was used with 7-(3-aminophenoxy)-1H-imidazo[4,5-b]-pyridin-2(3H)-one and 3-trifluoromethyl-5-chlorobenzoyl chloride to afford the title compound (28 mg, 29.8%). 1H-NMR (δ, ppm, DMSO-d6): 6.50 (d, 1H, HPy,5, J=5.9 Hz), 6.94-6.96 (m, 1H, Harom), 7.45 (t, 1H, Harom-5, J=8.2 Hz), 7.59 (s, 1H, Harom-2), 7.63-7.65 (m, 1H, Harom), 7.81 (d, 1H, HPy,6, J=5.9 Hz), 8.12 (s, 1H, Harom′), 8.22 (s, 1H, Harom′), 8.30 (s, 1H, Harom′), 10.60 (s, 1H, NHamide), 11.20 (s, 1H, NHPy7), 11.39 (s, 1H, NHPy9). LC-MS, tR=5.07 minutes, m/z: 448.06 (M+H)+, calculated for C20H13N4O3F3Cl. HRMS (EI): m/z [M+H] calculated for C20H13N4O3F3Cl: 449.0628; found: 449.0619.