反应详情

Method H2 was used with 7-(3-aminophenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one and 3-(1,1,2,2-tetrafluoroethoxy)benzoic acid to afford the title compound as a light pink solid (69 mg, 36%). 1H-NMR (δ, ppm, DMSO-d6): 6.49 (d, 1H, HPy,5, J=5.8 Hz), 6.86 (t, 1H, CF2H, J=51.7 Hz), 6.94 (d, 1H, Harom, J=7.2 Hz), 7.44 (t, 1H, Harom, J=8.2 Hz), 7.54 (d, 1H, Harom, J=7.6 Hz), 7.62-7.67 (m, 3H, Harom), 7.80-7.82 (m, 2H, Harom), 7.95 (d, 1H, Harom, J=7.8 Hz) 10.49 (s, 1H, NHamide), 11.25 (s, 1H, NHurea), 11.44 (s, 1H, NHurea). 13C-NMR (δ, ppm, DMSO-d6): 105.81 (CF2), 106.61, 107.79 (CF2) 110.90, 113.78, 114.68, 116.38, 120.76, 124.77, 126.26, 130.2, 130.40, 136.62, 140.51, 141.35, 144.60, 147.17, 148.04, 154.22, 154.75, 164.17. HRMS (EI): m/z [M+H] calcd for C21H14F4N4O4: 463.1024, found: 463.1022.