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HRID552695

反应详情

EQUATION

反应方程式

HRID 552695 的结构方程式

REACTANTS

反应物

3
结构：C1CCOC1
HCID8028

Tetrahydrofuran

C4H8O

结构：CO.N
HCID21705897

未命名化合物

结构：CC(=O)O[C@H]1C[C@H](n2cnc3c(N[C@H]4CCc5ccccc54)ncnc32)O[C@@H]1COS(N)(=O)=O
HCID86607295

未命名化合物

PRODUCTS

生成物

1
结构：NS(=O)(=O)OC[C@H]1O[C@@H](n2ccc3c(N[C@H]4CCc5ccccc54)ncnc32)[C@H](O)[C@@H]1O
HCID86607296

未命名化合物

收率 66%

PROCEDURE

实验过程

(2R,3S,5R)-2-{[(Aminosulfonyl)oxy]methyl}-5-{6-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-9H-purin-9-yl}tetrahydrofuran-3-yl acetate (96 mg, 0.20 mmol) was dissolved in 2.6 mL of 7M NH3/MeOH and stirred for one hour. Approximately 1 mL tetrahydrofuran was added, and the resulting solution was stirred for 3 hours. The solvent was removed in vacuo and the residue purified by silica gel chromatography (0% to 10% MeOH/CH2Cl2) to afford 59 mg (66%) of the title compound.

WORKUP

后处理

  1. stirringthe resulting solution was stirred for 3 hours
  2. customThe solvent was removed in vacuo
  3. customthe residue purified by silica gel chromatography (0% to 10% MeOH/CH2Cl2)