反应详情

Under the conditions of example 1 C, a solution of 1.89 g of 5-[3-methoxy-2-(2-methoxycarbonyl-(1E)-1-ethenyl)-6-pyridyl]-5-oxopentanoic acid methyl ester in 75 ml of methanol and 15 ml of tetrahydrofuran is hydrogenated in the presence 400 mg of 10% palladium catalyst and worked up. 1.9 g of 5-[3-methoxy-2-(2-methoxycarbonylethyl)-6-pyridyl]-(5RS)-5-hydroxypentanoic acid methyl ester is obtained as oil.