反应详情

2M Lithium borohydride in tetrahydrofuran (1.5 mL) was added to a solution of [3-({tert-butoxycarbonyl-[2-(2-fluoro-phenyl)-ethyl]-amino}-methyl)-4-methoxy-phenyl]-acetic acid methyl ester (0.25 g) in tetrahydrofuran (5 mL), at 0° C. under nitrogen. After 4 hours, the reaction was quenched by the addition of ethyl acetate. The reaction was diluted with ethyl acetate and extracted sequentially twice with saturated aqueous sodium bicarbonate solution, brine, dried (magnesium sulfate) and evaporated. Purification on silica, eluting with a gradient of methanol (0% to 1%) in dichloromethane, to give the subtitle compound as an oil (0.25 g).

1. customthe reaction was quenched by the addition of ethyl acetate
2. additionThe reaction was diluted with ethyl acetate
3. extractionextracted sequentially twice with saturated aqueous sodium bicarbonate solution, brine
4. dry with materialdried (magnesium sulfate)
5. customevaporated
6. customPurification on silica
7. washeluting with a gradient of methanol (0% to 1%) in dichloromethane