反应详情

To a methanol (0.2 mL)-THF (0.2 mL) solution of acetic acid [2R,3S,4R,5R]-2,3,4-trisbenzyloxy-5-benzyloxymethyl-1-[3-(4-methoxybenzyl)phenyl]cyclohexyl ester (4.2 mg), a 20% palladium hydroxide-carbon (3 mg) was added and the mixture solution was stirred under a hydrogen atmosphere for three hours. The reaction mixture was filtered and the filtrate was concentrated and the obtained residue was purified by preparative TLC [developing solution=dichloromethane:methanol (9:1)] to obtain the title compound (1.7 mg) as a single diastereomer.

1. filtrationThe reaction mixture was filtered
2. concentrationthe filtrate was concentrated
3. customthe obtained residue was purified by preparative TLC [developing solution=dichloromethane:methanol (9:1)]