反应详情

Following the procedure as described in Preparation 6, making variations as required to replace (S)-ethyl 2-(3-(4-fluorobenzyl)-4-methyl-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylate with ethyl 2-(3-(but-3-enyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylate, the title compound was obtained as a colourless solid (85%): mp 205-207° C.; 1H NMR (300 MHz, DMSO-d6) δ 12.70 (s, 1H), 5.86-5.72 (m, 1H), 5.16-5.02 (m, 2H), 4.01-3.96 (m, 2H), 3.60-3.54 (m, 2H), 3.31 (t, J=7.1 Hz, 2H), 2.50 (s, 3H), 2.32-2.26 (m, 2H); MS (ES+) m/z 281.8 (M+1).

1. customas described in Preparation 6