反应详情

Following the procedure as described in Preparation 6, making variations as required to replace (S)-ethyl 2-(3-(4-fluorobenzyl)-4-methyl-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylate with (R)-ethyl 2-(3-(4-fluorobenzyl)-4-methyl-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylate, the title compound was obtained as a colorless solid (87%): 1H NMR (300 MHz, DMSO-d6) δ 12.85 (s, 1H), 7.40-7.35 (m, 2H), 7.21-7.15 (m, 2H), 4.59 (d, J=15.6 Hz, 1H), 4.30 (d, J=15.6 Hz, 1H), 4.19 (t, J=9.6 Hz, 1H), 4.29-4.14 (m, 1H), 3.78-3.71 (m, 1H), 3.56 (dd, J=10.6, 6.3 Hz, 1H), 2.50 (s, 3H), 1.22 (d, J=6.2 Hz, 3H); MS (ES+) m/z 349.9 (M+1).

1. customas described in Preparation 6