反应详情

Following the procedure as described in Example 1, making variations as required to replace 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxylic acid with 2-(1-(cyclopropylmethyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxylic acid, the title compound was obtained as an off-white solid in 43% yield: mp 180-181° C. (ethanol/water); 1H NMR (300 MHz, DMSO-d6) δ 8.73 (s, 1H), 7.63 (br, 2H), 3.66 (d, J=7.0 Hz, 2H), 2.55 (s, 3H), 1.21-1.11 (m, 1H), 0.54-0.48 (m, 2H), 0.38-0.32 (m, 2H); 13C NMR (75 MHz, DMSO-d6) δ 162.6, 151.3, 150.9, 149.5, 131.4, 122.9, 49.4, 16.8, 10.0, 3.3; MS (ES+) m/z 280.3 (M+1).