反应详情

Following the procedure as describe in Example 12, making variations as required to replace (5-fluoropyridin-3-yl)methanamine with pyridin-3-ylmethanamine to react with 4-methyl-2-(2-oxo-3-(4,4,4-trifluorobutyl)imidazolidin-1-yl)thiazole-5-carboxylic acid in place of 2-(3-(cyclopropylmethyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acid, the title compound was obtained as a colorless solid in 50% yield: mp 167-169° C. (dichloromethane/hexanes); 1H NMR (300 MHz, CDCl3) δ 8.62-8.52 (m, 2H), 7.69-7.66 (m, 1H), 7.26-7.24 (m, 1H), 6.28-6.25 (m, 1H), 4.57 (d, J=5.9 Hz, 2H), 4.14-4.09 (m, 2H), 3.62-3.56 (m, 2H), 3.40-3.36 (m, 2H), 2.60 (s, 3H), 2.18-2.09 (m, 2H), 1.89-1.79 (m, 2H); MS (ES+) m/z 428.1 (M+1).