Hydrochloric Acid → HCID 178433891, compound

HRID 555610Notes

Reaction equation

HRID 555610 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:15](=[O:16])[C:14](=[CH:17][NH:18][NH:19][C:20](=[O:31])[C:21]3[CH:26]=[CH:25][C:24]([C:27]([O:29]C)=[O:28])=[CH:23][CH:22]=3)[C:13]([CH3:32])=[N:12]2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].Cl>CO>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([N:11]2[C:15](=[O:16])[C:14](=[CH:17][NH:18][NH:19][C:20](=[O:31])[C:21]3[CH:22]=[CH:23][C:24]([C:27]([OH:29])=[O:28])=[CH:25][CH:26]=3)[C:13]([CH3:32])=[N:12]2)=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178497996HCID 178497996, compound

Product 1

HCID 178433891HCID 178433891, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

59.4 mg (0.14 mmol) of the 4-methoxycarbonylbenzoic N′-(1-(4-tert-butylphenyl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene-methyl)-hydrazide synthesized in 2) was dissolved in 5.0 ml of methanol and stirred with 0.68 ml (0.68 mmol) of 1M aqueous sodium hydroxide at room temperature for 6 hours and then at 60° C. for 3 hours. After the stirring, 0.68 ml (0.68 mmol) of hydrochloric acid was added, and the precipitated solid was collected by filtration and dried to obtain 33.3 mg of the above-identified desired product as a yellow solid (yield 58%).

Workup

  1. filtrationthe precipitated solid was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-4a5076c87e3049388ccf4368e4b43720
Source dataset
uspto-grants-2011_11
Patent number
US08053453B2

Reaction notes

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