反应详情

A procedure similar to step 3 of Example 1 was used, 1-(4-methoxy-phenyl)-3-(4-nitro-phenyl)-propan-1-one prepared in the step 3 and bromide were used as starting materials, and anhydrous AlCl3 was used as catalyst, the obtained product was white crystal in a yield of 96.1%, mp: 120-122 └. 1H-NMR (CDCl3, 400 MHz) δ: 3.46 (1H, dd, J=14.28, 7.28 Hz), 3.74 (1H, dd, J=14.28, 7.28 Hz), 3.88 (3H, s, OCH3), 5.27 (1H, t, J=7.28 Hz, CHBr), 6.94 (2H, d, J=8.96 Hz, ArH), 7.46 (2H, d, J=8.60 Hz, ArH), 7.96 (2H, d, J=8.96 Hz, ArH), 8.16 (2H, d, J=8.60 Hz, ArH); ESI-MS: 366.1 (M+2, 93), 364.2 (M, 100).