反应详情

A procedure similar to step 3 of Example 1 was used. 3-(4-fluoro-phenyl)-1-(4-methoxy-phenyl)-propan-1-one prepared in the step 2 and bromide were used as starting materials, and anhydrous AlC3 was used as catalyst. The obtained product was a white solid in a yield of 95.0%, mp: 76-77 └. 1H-NMR (CDCl3, 400 MHz) δ: 3.31 (1H, dd, J=14.28, 7.00 Hz), 3.66 (1H, dd, J=14.28, 7.28 Hz), 3.87 (3H, s, OCH3), 5.23 (1H, t, J=7.56 Hz, CHBr), 6.93 (2H, d, J=8.96 Hz, ArH), 6.96 (2H, t, 3JFH=3JHH=8.72 Hz, ArH), 7.23 (2H, dd, 3JHH=8.68 Hz, 4JFH=5.60 Hz, ArH), 7.95 (2H, d, J=8.96 Hz, ArH); ESI-MS: 339.2 (M+2, 89), 337.0 (M, 70), 257.2 (100).