反应详情

A procedure similar to that in Example 7 was used. 3,4-dimethoxy-N-[5-(4-nitro-benzyl)-4-phenyl-thiazol-2-yl]-benzamide prepared in Example 29 and boron tribromide were used as starting materials. The obtained crude product was recrystallized with acetone and ethyl acetate to give a product as a white solid in a yield of 62.8%, mp: 244└(Dec.). 1H-NMR (DMSO-d6, 400 MHz) δ: 4.42 (2H, s, CH2), 6.81 (1H, d, J=8.40 Hz, ArH), 7.38 (1H, t, J=7.60 Hz, ArH), 7.44˜7.55 (6H, m, ArH), 7.64 (2H, d, J=8.44 Hz, ArH), 8.20 (2H, d, J=8.68 Hz, ArH), 9.32 (1H, br, OH), 9.81 (1H, br, OH), 12.38 (1H, br, CONH); EI-MS m/e (%): 447.1 (M+, 16), 311.1 (100); HREI-MS Calcd. for C23H17N3O5S: 447.0889. found: 447.0887.

1. customThe obtained crude product
2. customwas recrystallized with acetone and ethyl acetate