反应详情

A procedure similar to that in Example 7 was used. N-[5-benzyl-4-(4-methoxy-phenyl)-thiazol-2-yl]-4-methyoxy-benzamide prepared in Example 27 and boron tribromide were used as starting materials. The obtained crude product was recrystallized with acetone to give a product as a white solid in a yield of 41.3%, mp: 124-125 └. 1H-NMR (DMSO-d6, 400 MHz) δ: 3.84 (3H, s, CH3O), 4.21 (2H, s, CH2), 6.84 (2H, t, J=8.68 Hz, ArH), 7.06 (2H, t, J=8.68 Hz, ArH), 7.23˜7.26 (3H, m, ArH), 7.32˜7.36 (2H, m, ArH), 7.47 (2H, t, J=8.68 Hz, ArH), 8.08 (2H, t, J=8.96 Hz, ArH), 12.45 (1H, br, CONH); EI-MS m/e (%): 416.2 (M+, 62), 282.1 (4), 135.1 (100); HREI-MS Calcd. for C24H20N2O3S: 416.1195. found: 416.1194.

1. customThe obtained crude product
2. customwas recrystallized with acetone