反应详情

A procedure similar to that in Example 7 was used. N-[5-benzyl-4-(4-methoxy-phenyl)-thiazol-2-yl]-3-methyoxy-benzamide prepared in Example 42 and boron tribromide were used as starting materials. The obtained crude product was recrystallized with acetone to give a product as a white solid in a yield of 65.0%, mp: 233-234 └. 1H-NMR (DMSO-d6, 400 MHz) δ: 4.23 (2H, s, CH2), 6.83 (2H, d, J=7.28 Hz, ArH), 6.98˜7.02 (1H, m, ArH), 7.22˜7.35 (6H, m, ArH), 7.40 (1H, s, ArH), 7.46 (2H, d, J=7.28 Hz, ArH), 7.52 (1H, d, J=7.56 Hz, ArH), 9.50 (1H, br, OH), 12.50 (1H, br, CONH); EI-MS m/e (%): 402.1 (M+, 83), 121.0 (100); HREI-MS Calcd. for C23H18N2O3S: 402.1038, found: 402.1042.

1. customThe obtained crude product
2. customwas recrystallized with acetone