反应详情

A procedure similar to that in Example 7 was used. N-[5-benzyl-4-(4-methoxy-phenyl)-thiazol-2-yl]-4-methyoxy-benzamide prepared in Example 27 and boron tribromide were used as starting materials. The obtained crude product was recrystallized with acetone to give a product as a white solid in a yield of 67.9%, mp: 254-255 └. 1H-NMR (DMSO-d6, 400 MHz) δ: 4.20 (2H, s, CH2), 6.84 (4H, t, J=7.80 Hz, ArH), 7.20˜7.28 (3H, m, ArH), 7.33 (2H, t, J=8.08 Hz, ArH), 7.47 (2H, d, J=8.64 Hz, ArH), 7.97 (2H, d, J=8.60 Hz, ArH), 9.61 (1H, s, OH), 10.29 (1H, s, OH), 12.34 (1H, s, CONH); EI-MS m/e (%): 402.0 (M+, 82), 282.1 (74), 121.0 (100); HREI-MS Calcd. for C23H18N2O3S: 402.1038. found: 402.1027.

1. customThe obtained crude product
2. customwas recrystallized with acetone