反应详情

A procedure similar to step 3 of Example 1 was used. 3-cyclohexyl-1-(4-methoxy-phenyl)-propan-1-one prepared in the step 2 and bromide were used as starting materials, and anhydrous AlCl3 was used as catalyst, a colorless oily product was obtained in a yield of 96.6%. 1H-NMR (CDCl3, 400 MHz) δ: 0.85˜1.30 (5H, m), 1.45˜1.85 (6H, m), 2.04 (2H, t, J=8.08 Hz, CH2CHBr), 3.89 (3H, s, OCH3), 5.24 (1H, t, J=7.48 Hz, CHBr), 6.96 (2H, d, J=9.16 Hz, ArH), 8.02 (2H, d, J=8.68 Hz, ArH); ESI-MS m/e (%): 346.9 (M+Na, 100), 327.3 (M+1, 71).

1. customa colorless oily product was obtained in a yield of 96.6%