Sodium Acetate → 5-Cyclohexylmethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine
Reaction equation
Br[CH:2]([CH2:13][CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=1)=O.[NH2:20][C:21]([NH2:23])=[S:22].C([O-])(=O)C.[Na+]>>[CH:14]1([CH2:13][C:2]2[S:22][C:21]([NH2:23])=[N:20][C:3]=2[C:5]2[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=2)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1Participants
Procedure
A procedure similar to step 5 of Example 6 was used. 2-bromo-3-cyclohexyl-1-(4-methoxy-phenyl)-propan-1-one prepared in the step 3, thiourea and anhydrous sodium acetate were used as starting materials, refluxed for 3 hours, followed by post-treatment to give a crude product, which was purified under a reduced pressure by silica gel column chromatography eluted with petroleum ether and ethyl acetate at a ratio of 3:1 (V:V) to obtain a product as a white solid in a yield of 79.8%, mp: 118-119 └. 1H-NMR (CDCl3, 400 MHz) δ: 0.80˜0.92 (2H, m), 1.05˜1.25 (3H, m), 1.40˜1.50 (1H, m, CH), 1.60˜1.80 (5H, m), 2.59 (2H, d, J=7.04 Hz, CHCH2Ar), 3.83 (3H, s, OCH3), 5.55 (2H, br, NH2), 6.93 (2H, d, J=6.72 Hz, ArH), 7.44 (2H, d, J=6.72 Hz, ArH); EI-MS m/e (%): 302.2 (M+, 59), 219.1 (100), 177.1 (44); HREI-MS Calcd. for C17H22N2OS: 302.1453. found: 302.1450. Anal. Calcd. for C17H22N2OS: C, 67.51; H, 7.33; N, 9.26. found: C, 67.41; H, 7.47; N, 9.24.
Workup
- temperaturerefluxed for 3 hours
- customto give a crude product, which
- customwas purified under a reduced pressure by silica gel column chromatography
- washeluted with petroleum ether and ethyl acetate at a ratio of 3:1 (V:V)
Sources & evidence
- ORD record
- ord-0cf5e882a4474ba1a3cc9512c134ea25
- Source dataset
- uspto-grants-2011_11
- Patent number
- US08053581B2
Reaction notes
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