反应详情

A procedure similar to that in Example 7 was used. N-[5-n-butyl-4-(4-methoxy-phenyl)-thiazol-2-yl]-3,4-dimethoxy-benzamide prepared in Example 63 and boron tribromide were used as starting materials, the crude product was purified by recrystallization with acetone to give a product as a white solid in a yield of 43.6%, mp: 189-190 └. 1H-NMR (DMSO-d6, 400 MHz) δ: 0.88 (3H, t, J=7.2 Hz, CH3), 1.35 (2H, sextuple, J=7.20 Hz, CH2), 1.62 (2H, quintuple, J=7.20 Hz, CH2), 2.82 (2H, t, J=7.2 Hz, CH3), 6.07 (3H, br, OH), 7.65˜7.85 (3H, m, ArH), 7.32˜7.52 (4H, m, ArH), 12.12 (1H, br, CONH); EI-MS m/e (%): 384.1 (M+, 37), 248.2 (83), 205.1 (100); HREI-MS Calcd. for C20H20N2O4S: 384.1144. found: 384.1146.

1. customthe crude product was purified by recrystallization with acetone