反应详情

A procedure similar to that in Example 7 was used. N-[5-n-butyl-4-(4-methoxy-phenyl)-thiazol-2-yl]-3,4,5-trimethoxy-benzamide prepared in Example 64 and boron tribromide were used as starting materials, the crude product was purified by recrystallization with acetone to give a product as a white solid in a yield of 47.5%, mp: 119-120 └. 1H-NMR (DMSO-d6, 400 MHz) δ: 0.88 (3H, t, J=7.2 Hz, CH3), 1.35 (2H, sextuple, J=7.20 Hz, CH2), 1.63 (2H, quintuple, J=7.20 Hz, CH2), 2.82 (2H, t, J=7.2 Hz, CH3), 6.83 (2H, d, J=8.80 Hz, ArH), 7.08 (2H, s, ArH), 7.40 (2H, d, J=8.80 Hz, ArH), 8.80 (4H, br, OH), 12.12 (1H, br, CONH); EI-MS m/e (%): 400.1 (M+, 14), 248.2 (55), 205.1 (100), 163.1 (38); HREI-MS Calcd. for C20H20N2O5S: 400.1093. found: 400.1091.

1. customthe crude product was purified by recrystallization with acetone