Ethylene Glycol → 1-[4-(Difluoromethoxy)phenyl]cyclopropanecarboxylic acid

Temperature

100 °C

Sodium hydroxide [50% aqueous solution (3.20 g)], was added to a mixture of [4-(difluoromethoxy)phenyl]acetonitrile (1.00 g, 5.4 mmol), benzyltriethylammonium chloride (0.10 g, 0.4 mmol) and 1-bromo-2-chloro-ethane (1.58 g, 11.0 mmol) at 50° C. overnight. 1,2-Ethanediol (10.00 mL) was then added to the mixture, and the resulting mixture was heated at 100° C. overnight. The mixture was then poured into ice-water (30 mL) and the resulting mixture was then extracted with ethyl ether (2×10 mL). The aqueous phase was acidified (pH=2) with 1N aqueous HCl solution, and then was extracted with ethyl acetate (4×15 mL). The combined organic phase was washed with brine (10 mL), then dried over Na2SO4, then filtered, and then concentrated under reduced pressure. The residue was the desired product which was directly used in the reaction of next step without further room temperature purification.

1. extractionthe resulting mixture was then extracted with ethyl ether (2×10 mL)
2. extractionwas extracted with ethyl acetate (4×15 mL)
3. washThe combined organic phase was washed with brine (10 mL)
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure
7. customwas directly used in the reaction of next step without further room temperature
8. custompurification

ORD record

ord-017749c60f2e481789cfe922bf308a97

Source dataset

uspto-grants-2011_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08058288B2