反应详情

110 mg (0.2 mmol) of compound from Example 86 above, 3-(4-bromophenyl)-1,9-dimethyl-6-[5-(tetrahydropyran-2-yloxymethyl)-2H-pyrazol-3-yl]-1,9-dihydropyrido[2,3-b]indol-2-one are dissolved in 6 ml of MeOH. A spatula tip of p-toluenesulphonic acid is added and the mixture is refluxed overnight. The reaction medium is evaporated to dryness. A saturated NaHCO3 solution is added and the mixture is extracted with EtOAc. The organic phase is evaporated to dryness. The product obtained is triturated in water, filtered and washed with water. The product is taken up in methanol and evaporated to dryness.

1. temperaturethe mixture is refluxed overnight
2. customThe reaction medium is evaporated to dryness
3. additionA saturated NaHCO3 solution is added
4. extractionthe mixture is extracted with EtOAc
5. customThe organic phase is evaporated to dryness
6. customThe product obtained
7. customis triturated in water
8. filtrationfiltered
9. washwashed with water
10. customevaporated to dryness