反应详情

温度

0 °C

13.8 ml (22.14 mmol) of a 1.6N solution of n-butyllithium in hexane were added dropwise to a solution of 4.7 ml (22.14 mmol) of hexamethyldisilazane in 17 ml of tetrahydrofuran at −20° C., and the mixture was stirred at 0° C. for 30 min and then cooled again to −78° C. 2.17 ml (22.14 mmol) of ethyl acetate were added, and the mixture was stirred for 30 min and, after addition of 2.00 g (11.07 mmol) of 4-chlorophenyl cyclopropyl ketone, dissolved in 17 ml of tetrahydrofuran, stirred at −78° C. for a further hour. The reaction solution was mixed with 1N hydrochloric acid and ethyl acetate, and the phases were separated. The organic phase was washed successively with 0.5N hydrochloric acid, water and saturated aqueous sodium chloride solution, dried over sodium sulfate, filtered and concentrated. After purification of the crude product by preparative HPLC (mobile phase: acetonitrile/water gradient) the acetonitrile was removed in a rotary evaporator, and the aqueous phase was extracted several times with diethyl ether. The combined organic phases were washed with saturated aqueous sodium chloride solution, dried over sodium sulfate, filtered and concentrated. 2.54 g (99% of theory) of the title compound were obtained.

1. temperaturecooled again to −78° C
2. stirringthe mixture was stirred for 30 min
3. stirringstirred at −78° C. for a further hour
4. customthe phases were separated
5. washThe organic phase was washed successively with 0.5N hydrochloric acid, water and saturated aqueous sodium chloride solution
6. dry with materialdried over sodium sulfate
7. filtrationfiltered
8. concentrationconcentrated
9. customAfter purification of the crude product by preparative HPLC (mobile phase: acetonitrile/water gradient) the acetonitrile
10. customwas removed in a rotary evaporator
11. extractionthe aqueous phase was extracted several times with diethyl ether
12. washThe combined organic phases were washed with saturated aqueous sodium chloride solution
13. dry with materialdried over sodium sulfate
14. filtrationfiltered
15. concentrationconcentrated