Benzenemethanol, alpha-cyclopropyl-alpha-methyl-4-(trifluoromethyl)- → 3-{1-Cyclopropyl-1-[4-(trifluoromethyl)phenyl]ethyl}-7-[(methylsulfanyl)methyl]-1H-indole

HRID 561635Notes

Reaction equation

HRID 561635 reaction equation
[CH3:1][S:2][CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][CH:10]=[CH:9]2.[CH:13]1([C:16]([C:19]2[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=2)(O)[CH3:17])[CH2:15][CH2:14]1.ClC1C=CC(C(C2C3C(=C(CSC)C=CC=3)NC=2)(C2CC2)C)=CC=1>>[CH:13]1([C:16]([C:9]2[C:8]3[C:12](=[C:4]([CH2:3][S:2][CH3:1])[CH:5]=[CH:6][CH:7]=3)[NH:11][CH:10]=2)([C:19]2[CH:20]=[CH:21][C:22]([C:25]([F:26])([F:27])[F:28])=[CH:23][CH:24]=2)[CH3:17])[CH2:15][CH2:14]1

Participants

4

Reactant 3

HCID 23255822Benzenemethanol, alpha-cyclopropyl-alpha-methyl-4-(trifluoromethyl)-HCID 583921877-[(Methylsulfanyl)methyl]-1H-indoleHCID 583922903-[1-(4-Chlorophenyl)-1-cyclopropylethyl]-7-[(methylsulfanyl)methyl]-1H-indole

Product 1

HCID 583921903-{1-Cyclopropyl-1-[4-(trifluoromethyl)phenyl]ethyl}-7-[(methylsulfanyl)methyl]-1H-indole

Procedure

The title compound was prepared starting from 462 mg (2.61 mmol) of the compound from Example 8A and 600 mg (2.61 mmol) of the compound from Example 139A in analogy to the synthesis of the compound from Example 184. 273 mg (27% of theory) of the target compound were obtained.

Workup

  1. custom273 mg (27% of theory) of the target compound were obtained

Sources & evidence

ORD record
ord-7fc8426b095e48da80055c39e77035f8
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

Loading…