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HRID561989

反应详情

EQUATION

反应方程式

HRID 561989 的结构方程式

REACTANTS

反应物

6
结构：O=C1CCC(=O)N1Cl
HCID31398

N-Chlorosuccinimide

C4H4ClNO2

结构：COCCBr
HCID80972

Ethane, 1-bromo-2-methoxy-

C3H7BrO

结构：CC(C)[C@@H](c1ncc(-c2ccc(I)cc2)[nH]1)N1C(=O)N[C@H](CCC(=O)O)C1=O
HCID57771978

未命名化合物

结构：CN(C)C(=O)COc1ccc([C@@H](NC(=O)OC(C)(C)C)C(=O)O)cc1
HCID66815126

未命名化合物

结构：CC(C)(C)OCCOc1ccc([C@@H](NC(=O)OC(C)(C)C)C(=O)O)cc1
HCID66815165

未命名化合物

2 次

结构：C[C@@H](c1ccccc1)[C@H](NC(=O)OC(C)(C)C)c1ncc(-c2ccccc2F)[nH]1
HCID67001749

未命名化合物

PRODUCTS

生成物

1
结构：COCCOc1ccc([C@@H](NC(=O)OC(C)(C)C)C(=O)O)cc1
HCID66815175

未命名化合物

PROCEDURE

实验过程

Prepared by the same method as described in example 1 except that (i) (2S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid was used in place of (2S,3S)-2-tert-butoxycarbonylamino-3-phenyl-butyric acid in step 53-E; (ii) chlorination of the 5-position of the imidazole ring with N-chlorosuccinimide in step 53-F was omitted and (iii) (R)-tert-butoxycarbonylamino-[4-(2-methoxy-ethoxy)-phenyl]-acetic acid was in place of (R)-tert-butoxycarbonylamino-[4-(2-tert-butoxy-ethoxy)-phenyl]-acetic acid in step 53-G. (R)-tert-Butoxycarbonylamino-[4-(2-methoxy-ethoxy)-phenyl]-acetic acid was prepared as described in example 1 for the preparation of (R)-tert-butoxycarbonylamino-[4-(2-tert-butoxy-ethoxy)-phenyl]-acetic acid except that 1-bromo-2-methoxy-ethane was used in place of 2-(2-iodo-ethoxy)-2-methyl-propane. HR-MS: calcd for C29H26FlN4O4 [M+H+] 641.1056. Found 641.1053.

WORKUP

后处理

  1. customPrepared by the same method