反应详情

The title compound was synthesized in similar fashion to rel-N-{2-[((3R,4R)-1-{1-[4-(morpholin-4-ylcarbonyl)phenyl]piperidin-4-yl}-4-propoxypyrrolidin-3-yl)amino]-2-oxoethyl}-3-(trifluoromethyl)benzamide substituting 1-(4-methoxyphenyl)piperidin-4-one for 1-[4-(morpholin-4-ylcarbonyl)phenyl]piperidin-4-one and was isolated as a white solid. 1H-NMR (CDCl3) δ: 0.91 (m, J=7.2 Hz, 3H), 1.52-1.74 (m, 4H), 1.93-1.96 (m, 2H), 2.27-2.44 (m, 2H), 2.62-2.69 (m, 2H), 2.78-2.93 (m, 2H), 3.36-3.51 (m, 4H), 3.56-3.64 (m, 1H), 3.76 (s, 3H), 4.14 (d, J=4.8 Hz, 2H), 4.31-4.36 (m, 1H), 6.69-6.71 (m, 1H), 6.81-6.91 (m, 4H), 7.20-7.23 (m, 1H), 7.56 (t, J=7.5 Hz, 1H), 7.76 (d, J=7.5 Hz, 1H), 8.01 (d, J=7.2 Hz, 1H), 8.11 (s, 1H). MS m/z: 563 (M+1).

1. customwas isolated as a white solid