反应详情

A solution of 1′-tert-butoxycarbonyl-spiro[3H-indole-3,4′-piperidin]-2(1H)-one, as described above in Step A, (551 mg, 1.70 mmol) in ethyl acetate saturated with HCl (5 mL) was stirred at ambient temp. for 3 hours as the product salt slowly crystallized out. This salt was collected by filtration and partitioned between methylene chloride and aqueous sat'd. sodium carbonate. The organic layer was separated off, dried (anhyd. sodium sulfate) filtered, and the solvent removed under vacuum. The residue was triturated with diethyl ether to give the title compound as a white solid, mp: 184-186° C.

1. customslowly crystallized out
2. filtrationThis salt was collected by filtration
3. custompartitioned between methylene chloride and aqueous sat'd
4. customThe organic layer was separated off
5. dry with materialdried (anhyd. sodium sulfate)
6. filtrationfiltered
7. customthe solvent removed under vacuum
8. customThe residue was triturated with diethyl ether