反应详情

N-(2-Hydroxyethyl)-6-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]hexanesulfonamide (7.75 g, 15.69 mmol) prepared in the same manner as in Example 19 was dissolved in ethanol. A 15% HCl-methanol solution was added thereto to make it acidic, and the solvent was removed by evaporation in vacuo. Diethyl ether was added to the residue, and the precipitated crystals were collected by filtration. The crystals were recrystallized from ethanol, to give N-(2-hydroxyethyl)-6-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]hexanesulfonamide dihydrochloride (8.10 g) as colorless prisms (yield: 91.1%).

1. customthe solvent was removed by evaporation in vacuo
2. additionDiethyl ether was added to the residue
3. filtrationthe precipitated crystals were collected by filtration
4. customThe crystals were recrystallized from ethanol