反应详情

2.5 g (97 mmol) of 2-amino-3-ethoxycarbonyl-5-(4-nitrophenyl)pyrrole, 19.4 ml of formamide, 9.7 ml of DMF and 3.1 ml of formic acid are stirred at 150° C. together for 22 h. 1 ml of isopropanol is added to the warm reaction mixture. After cooling the reaction mixture, the precipitated product is filtered off. It is washed successively three times with 10 ml of ethanol each time, twice with 10 ml of isopropanol each time and twice with 10 ml of hexane each time. 4-Hydroxy-6-(4-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidine is obtained as rust-brown crystals which are employed for the next stage; MS: (M)+=256.

1. temperatureAfter cooling the reaction mixture
2. filtrationthe precipitated product is filtered off
3. washIt is washed successively three times with 10 ml of ethanol each time